Thanks for welcoming me onto the board.
I performed a clean install of OS 10.10 on a MacBookPro last night with no issues.
The USB BU-353S4 is no longer visible in the system report and the only options when running the GPS utility are Bluetooth. The LED status lights do not illuminate.
I have removed prolificusbserial and re-installed PL2303_1.5.1_20130822
Thanks for looking into this.